SubtiBank SubtiBank
bshC [2017-8-11 16:0:3]
You are currently viewing an outdated version of SubtiWiki. Please use the newest version!

bshC [2017-8-11 16:0:3]

cysteine-adding enzyme required for the synthesis of bacillithiol
Locus
BSU15120
Isoelectric point
5.25
Molecular weight
62.44 kDa
Protein length
539 aa Sequence Blast
Gene length
1617 bp Sequence Blast
Function
biosynthesis of bacillithiol
Product
cysteine-adding enzyme
Essential
no
Synonyms
yllA
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      
Loading

Categories containing this gene/protein

  • Metabolism → Additional metabolic pathways → Miscellaneous metabolic pathways → Biosynthesis of bacillithiol
  • Lifestyles → Coping with stress → Resistance against oxidative and electrophile stress

    • Gene

    Coordinates
    1,578,376 → 1,579,995

    Phenotypes of a mutant

  • impaired growth in minimal medium, reduced activity of enzymes containing FeS cluster PubMed
  • sensitivity to superoxide (paraquate) stress PubMed

    • The protein

    Structure

  • 4WBD PubMed

    • Expression and Regulation

    Operons

    Genes
    ylbQ-bshC
    Description
    PubMed

    Sigma factors

  • SigA: sigma factor, PubMed, in SigA regulon

    • Regulatory mechanism

  • Spx: activation, PubMed, in Spx regulon

    • Regulation

  • ylbQ: induced by diamide stess (thiol depletion) (Spx) PubMed
    • view in new tab

    Biological materials

    Mutant

  • MGNA-B128 (bshC::erm), available at the NBRP B. subtilis, Japan
  • a bshC null mutant is available in John Helmanns lab

    • References

    Reviews

    Loading

    Original Publications

    Loading